![]() ![]() Mechanical properties, and cell viability will be discussed. Title:Cross-linked Electrospun Fibrous Scaffolds for Tissue EngineeringĪuthor(s): Xiaoming Xu and Jian-Feng ZhangĪbstract: The structures of scaffolds for tissue engineering have significant effects on the seeding, migration, and proliferation Keywords: Electrospinning, nanofibers, chemical cross-linking agent, physical cross-linking, photo-cross-linking, solvent resistance, biocompatibility, mechanical properties, hydrophilic, biochemistry. Novel nanofibrous scaffolds with enhanced solvent resistance and mechanical strength as well as tunable biodegradation To mimic the nano-fibrous architecture, a few technologies have been developed to engineer nano-fibrous scaffolds. Such as genipin and the reactive electrospinning with in-situ photo-cross-linking are promising new technologies to fabricate Collagen is a major natural extracellular matrix component, and possesses a fibrous structure with fiber bundles varying in diameter from 50-500 nm 124, 125. In addition, electrospinning can be used to fabricate porous micro- and nanofibers, as well as various types of hierarchically controlled fibrous structures, ranging from 1 to 3D fibrous scaffolds. Chemical cross-linking with nontoxic cross-linkers Their effects on solvent resistance, biocompatibility, In this article, we will review theĬurrent technologies for fabricating cross-linked fibrous scaffolds by the combination of electrospinning and differentĬross-linking methods including chemical, physical and photo-cross-linking. Cross-linking has been proven an effective method for stabilizingįibrous structure and improving mechanical properties of the fibrous scaffolds. In aqueous conditions such as body fluid and culture media. Scholarship Program issued by the Dutch Ministry of Education. However, water-soluble and hydrophilic polymeric microfibers and nanofibers lose their fibrous morphology Fibrous scaffolds for musculoskeletal tissue engineering NWO (Veni grant no. Fibrous scaffolds consisting of microfibers or nanofibers have attracted increasing attention andĪpplications in tissue engineering because of their high porosity and surface area and their ability to direct cell growth andĪlignment. The structures of scaffolds for tissue engineering have significant effects on the seeding, migration, and proliferation
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